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    A nonmetallic chemical component that is an essential element for all life, looks like oxygen in chemical residential or commercial properties, and is utilized particularly in the form of sulfuric acid to extract phosphates from ores. [1]


    Sulfur is a chemical aspect that is present in all living tissues. After calcium and phosphorus, it is the 3rd most abundant mineral in the body. Sulfur is likewise discovered in garlic, onions, and broccoli.

    Sulfur is applied to the skin for dandruff and a scratchy skin infection caused by termites (scabies). It is likewise applied to the skin for acne and skin redness (rosacea), and taken orally for numerous other conditions, however there is limited scientific evidence to support these uses. [2]



    Being abundantly offered in native form, sulfur was known in ancient times and is referred to in the torah (genesis). English translations of the christian bible frequently described burning sulfur as “brimstone”, giving rise to the term “fire-and-brimstone” preachings, in which listeners are advised of the fate of eternal damnation that await the unbelieving and unrepentant. It is from this part of the bible that hell is suggested to “smell of sulfur” (likely due to its association with volcanic activity). According to the ebers papyrus, a sulfur ointment was utilized in ancient egypt to deal with granular eyelids. Sulfur was utilized for fumigation in preclassical greece; this is discussed in the odyssey. Pliny the elder talks about sulfur in book 35 of his natural history, saying that its best-known source is the island of melos. He discusses its use for fumigation, medication, and lightening fabric.

    A natural type of sulfur known as shiliuhuang (石硫黄) was understood in china because the 6th century bc and discovered in hanzhong. By the 3rd century, the chinese had discovered that sulfur could be drawn out from pyrite. Chinese daoists were interested in sulfur’s flammability and its reactivity with specific metals, yet its earliest useful uses were discovered in traditional chinese medicine. A tune dynasty military treatise of 1044 advertisement explained different formulas for chinese black powder, which is a mix of potassium nitrate (kno3), charcoal, and sulfur. It stays a component of black gunpowder.

    Indian alchemists, specialists of the “science of chemicals” (sanskrit: रसशास्त्र, romanized: rasaśāstra), composed thoroughly about making use of sulfur in alchemical operations with mercury, from the 8th century ad onwards. In the rasaśāstra tradition, sulfur is called “the stinky” (गन्धक, gandhaka).

    Early european alchemists offered sulfur an unique alchemical sign, a triangle at the top of a cross (). The astrological symbol for 2 pallas, a crossed spear (⚴), has actually been released in numerous forms, including one that appears like the sign for sulfur. In traditional skin treatment, essential sulfur was utilized (generally in creams) to alleviate such conditions as scabies, ringworm, psoriasis, eczema, and acne. The.

    Mechanism of action is unidentified– though essential sulfur does oxidize gradually to sulfurous acid, which is (through the action of sulfite) a moderate reducing and antibacterial representative.

    Modern times

    Right: today sulfur is known to have antifungal, anti-bacterial, and keratolytic activity; in the past it was utilized against acne vulgaris, rosacea, seborrheic dermatitis, dandruff, pityriasis versicolor, scabies, and warts. This 1881 advertisement baselessly declares effectiveness against rheumatism, gout, baldness, and graying of hair.

    Sulfur appears in a column of repaired (non-acidic) alkali in a chemical table of 1718. Antoine lavoisier used sulfur in combustion experiments, writing of a few of these in 1777.

    Sulfur deposits in sicily were the dominant source for more than a century. By the late 18th century, about 2,000 tonnes annually of sulfur were imported into marseille, france, for the production of sulfuric acid for usage in the leblanc procedure. In industrializing britain, with the repeal of tariffs on salt in 1824, demand for sulfur from sicily rose up. The increasing british control and exploitation of the mining, refining, and transport of the sulfur, coupled with the failure of this profitable export to transform sicily’s backward and impoverished economy, resulted in the sulfur crisis of 1840, when king ferdinand ii provided a monopoly of the sulfur market to a french company, breaching an earlier 1816 trade agreement with britain. A peaceful service was ultimately negotiated by france.

    In 1867, elemental sulfur was found in underground deposits in louisiana and texas. The extremely effective frasch process was established to extract this resource.

    In the late 18th century, furniture makers utilized molten sulfur to produce ornamental inlays. Molten sulfur is in some cases still utilized for setting steel bolts into drilled concrete holes where high shock resistance is desired for floor-mounted devices accessory points. Pure powdered sulfur was used as a medicinal tonic and laxative.

    With the advent of the contact procedure, the majority of sulfur today is used to make sulfuric acid for a wide range of uses, especially fertilizer.

    In current times, the primary source of sulfur has actually become petroleum and natural gas. This is due to the requirement to eliminate sulfur from fuels in order to avoid acid rain, and has led to a surplus of sulfur.

    Spelling and etymology

    Sulfur is derived from the latin word sulpur, which was hellenized to sulphur in the erroneous belief that the latin word originated from greek. This spelling was later reinterpreted as representing an/ f/ sound and led to the spelling sulfur, which appears in latin towards completion of the classical period. The true greek word for sulfur, θεῖον, is the source of the worldwide chemical prefix thio-. In 12th-century anglo-french, it was sulfre. In the 14th century, the mistakenly hellenized latin -ph- was brought back in middle english sulphre. By the 15th century, both complete latin spelling variants sulfur and sulphur became common in english. The parallel f ~ ph spellings continued in britain up until the 19th century, when the word was standardized as sulphur. On the other hand, sulfur was the kind picked in the united states, whereas canada utilizes both. The iupac embraced the spelling sulfur in 1990 or 1971, depending on the source pointed out, as did the classification committee of the royal society of chemistry in 1992, restoring the spelling sulfur to britain. Oxford dictionaries keep in mind that “in chemistry and other technical usages … The -f- spelling is now the basic kind for this and related words in british along with us contexts, and is progressively utilized in general contexts as well. [3]

    Physical properties of sulfur

    Sulfur has an atomic weight of 32.066 grams per mole and is part of group 16, the oxygen household. It is a nonmetal and has a specific heat of 0.706 j g-1 oc-1. The electron affinity if 200 kj mol-1 and the electronegativity is 2.58 (system less). Sulfur is usually found as a light-yellow, nontransparent, and brittle strong in big amounts of small orthorhombic crystals. Not just does sulfur have two times the density of water, it is likewise insoluble in water. On the other hand, sulfur is highly soluble in carbon disulfide and a little soluble in lots of typical solvents. Sulfur can also differ in color and blackens upon boiling due to carbonaceous pollutants. Even just 0.05% of carbonaceous matter darkens sulfur substantially.

    Most sulfur is recuperated directly as the aspect from underground deposits by injecting super-heated water and piping out molten sulfur (sulfur melts at 112o c). Compared to other components, sulfur has the most allotropes. While the s8 ring is the most common allotrope, there are 6 other structures with as much as 20 sulfur atoms per ring.

    • Under appropriate conditions, sulfur vapor can include \( s \), \( s_2 \), \( s_4 \), \( s_6 \), and \( s_8 \).
    • At room temperature level, rhombic sulfur (sα) is a steady solid consisted of cyclic \( s_8 \) molecules.
    • At 95.5 ° c, rhombic sulfur ends up being monoclinic sulfur (sβ). The crystal structure discovered in monoclinic sulfur varies from that of rhombic sulfur. Monoclinic sulfur is likewise comprised of \( s_8 \) particles.
    • Monoclinic sulfur becomes liquid sulfur (sλ) at 119 ° c. Liquid sulfur is straw-colored liquid made up of \( s_8 \) molecules and other cyclic particles containing a series of 6 to twenty atoms.
    • At 160 oc, this ends up being a dark, thick liquid called liquid sulfur (sμ). The particles are still made up of 8 sulfur atoms however the molecule opens up and transforms from a circle into a long spiral-chain molecule.
    • At 180 ° c, the chain length and viscosity reach their optimum. Chains break and viscosity reduces at temperatures that go beyond 180 ° c.
    • Sulfur vapor is produced when liquid boils at 445 ° c. In the vapor that is produced, \( s_8 \) particles dominate however as the vapor continues to heat up, the particles break up into smaller sized groups of sulfur.
    • To produce plastic sulfur, sis poured into cold water. Plastic sulfur is rubberlike and is made up of long, spiral-chain particles. If plastic sulfur sits for long, it will reconvert to rhombic sulfur. [4]

    System of action

    Sulfur functions as a keratolytic representative and likewise it has anti-bacterial activity. It also eliminates fungis, scabies termites and other parasites. Sped up sulfur and colloidal sulfur are utilized, in form of lotions, creams, powders,.

    Soaps, and bath ingredients, for the treatment of acne vulgaris, acne rosacea, and seborrhoeic dermatitis. [5]

    Foods and drinks rich in sulfur

    Sulfur is found in a big variety of foods. The most significant categories consist of.

    • Meat and poultry: especially beef, ham, chicken, duck, turkey, and organ meats like heart and liver
    • Fish and seafood: most types of fish, in addition to shrimp, scallops, mussels, and prawns
    • Legumes: specifically soybeans, black beans, kidney beans, divided peas, and white beans
    • Nuts and seeds: specifically almonds, brazil nuts, peanuts, walnuts, and pumpkin and sesame seeds
    • Eggs and dairy: whole eggs, cheddar, parmesan and gorgonzola cheese, and cow’s milk
    • Dried fruit: particularly dried peaches, apricots, sultanas, and figs
    • Certain vegetables: particularly asparagus, broccoli, brussels sprouts, red cabbage, leeks, onion, radishes, turnip tops, and watercress
    • Specific grains: specifically pearl barley, oats, wheat, and flour made from these grains
    • Specific beverages: particularly beer, cider, wine, coconut milk, and grape and tomato juice
    • Dressings and spices: especially horseradish, mustard, marmite, curry powder, and ground ginger

    Drinking water can likewise include significant amounts of sulfur depending on where you live. This may be specifically real if you source your water from a well.

    Additionally, sulfites– a food preservative stemmed from sulfur– are typically added to packaged foods like jams, pickles, and dried fruit to extend their life span. Sulfites can likewise develop naturally in fermented foods and drinks consisting of beer, wine, and cider.


    Sulfur is naturally discovered in a variety of foods and drinks. Sulfur-derived sulfite is another type of sulfur frequently contributed to some packaged foods. [6]

    Uses of sulfur

    Supplement use should be embellished and vetted by a health care professional, such as a registered dietitian, pharmacist, or doctor. No supplement is planned to deal with, cure, or prevent an illness.

    Sulfur plays an essential role in the body. It is essential for the production of key proteins and the building blocks of those proteins, which are called amino acids. For example, sulfur is required for the synthesis, or creation, of the amino acids cysteine and methionine. These amino acids become part of a powerful antioxidant called glutathione.

    Although there is little research available on sulfur, there are few circumstances in which sulfur supplementation might be helpful.

    What is an antioxidant?

    Anti-oxidants are substances in your body that can prevent cell damage, so they defend you against various types of diseases and diseases.

    Joint and muscle discomfort

    Sulfur is part of standard treatments used worldwide for a range of conditions.


    Msm, a naturally happening sulfur substance found in many foods, might help those with different osteoarthritis types.

    It is recommended that msm supplements might work as an anti-inflammatory that might potentially safeguard cartilage. For those with arthritis, the result might be less pain and a much better series of motion in the joints. Nevertheless, research study in this area is limited and mixed.

    A few research studies have actually shown improvements in pain and physical function when supplementing with msm. An early pilot trial randomized 50 individuals with knee osteoarthritis (oa) to get 3 grams msm twice everyday or placebo for 12 weeks. Those that got the msm supplement reported improved discomfort symptoms and physical function. Nevertheless, the benefit and security of msm for this use and its long-lasting application can’t be confirmed.

    An extra study found comparable results when they randomized 49 people with knee oa to get 1.125 grams msm three times daily versus placebo for 12 weeks. The authors kept in mind that the enhancement in pain and physical function with msm was little and the research study did not figure out if it was a medically significant modification.

    Another research study assessed a supplement that contained msm in combination with numerous other active ingredients (glucosamine sulfate, white will bark extract, ginger root concentrate, boswella serrata extract, turmeric root extract, cayenne, and hyaluronic acid). One hundred people with a history of joint discomfort were randomized to receive the supplement or placebo for 8 weeks. While those who took the supplement reported reduced joint pain, there was no effect on markers of inflammation or improvement on a six-minute walk test.

    A separate meta-analysis discovered that neither dmso nor msm worked in decreasing pain from oa. It ought to be noted that this meta-analysis was performed in 2009 and did not include 2 of the research studies discussed previously.

    Further research is still required to figure out the benefits of supplementing sulfur, what the appropriate dose ought to be, and whether it is better to supplement sulfur by itself or in a combination with other active ingredients.


    Balneotherapy is an alternative therapy that’s been utilized for centuries to ease joint and muscle pain. Balneotherapy involves bathing inflamed or stressed out joints and muscles in warm springs and water which contains sulfur along with other rich minerals.

    Research is blended regarding the efficiency of balneotherapy. It’s been thought to decrease pain and enhance the lifestyle for those with osteoarthritis. However, a 2015 study evaluation found there wasn’t enough proof to show it aided with signs of rheumatoid arthritis.

    The bottom line on balneotherapy: it can be utilized along with other treatments to minimize low-grade inflammation and stress-related pain or tightness. However, it is still advised to receive treatment from a doctor to alleviate the signs of your condition better.

    Allergic reactions

    As an anti-inflammatory, msm appears to minimize the inflammation set off by unusual immune reactions, which affects individuals who have allergies to food or ecological factors.

    In a randomized, double-blind study, scientists revealed that msm significantly reduced allergy symptoms. Taking 3 grams of msm daily for 2 weeks assisted those with allergies breathe much better and reduced their nasal congestion. More research is required.


    Dandruff is a skin problem on the scalp that causes itching, flaking skin, and possible inflammation and inflammation. Sulfur is approved by the food and drug administration (fda) for usage in over-the-counter dandruff items that often include salicylic acid.

    Little research has been done considering that a small 1987 study of people with dandruff. That research study showed that when people utilized shampoo containing sulfur and salicylic acid, they reported less scaling and dandruff. Further studies would assist to examine the efficiency of sulfur for dandruff.


    Rosacea is a skin condition that looks like adult acne however is very various. It triggers red, swollen locations on the face, red bumps, and an augmentation of the nose.

    Mix sulfur solutions containing 10% sodium sulfacetamide and 5% sulfur have actually been shown to considerably lower soreness and sores brought on by rosacea. These topical formulas, indicating creams or lotions applied to the skin, also seem to have couple of negative effects. Nevertheless, some people are hypersensitive to sulfur products.

    Interstitial cystitis

    Interstitial cystitis (ic) is persistent bladder inflammation. The fda has authorized dmso for the treatment of ic. It becomes part of a liquid solution that is placed into the bladder. This requires a health care practitioner. Anesthesia is typically needed for the treatment.

    Extra claims

    Many other claims about sulfur do not have the research to support them. It has not been revealed to aid with menopause symptoms, enhance nails, or deal with persistent obstructive lung disease (copd), hyperlipidemia, or fight cancer. [7]

    Advantages of sulfur for skin

    A few of the characteristics of sulfur that make it excellent as an acne treatment (for instance, its anti-inflammatory and antibacterial residential or commercial properties) are likewise useful for dealing with a variety of other skin concerns.

    Dries blemishes: according to shah, sulfur reduces sebum (oil) on the skin. When applied to the blemish, sulfur works to dry the skin so it can then be sloughed away.

    Promotes exfoliation: sulfur works to exfoliate dead skin and get rid of pollutants: shah says that sulfur has a keratolytic effect (suggesting it works to soften and thin the skin), which assists remove dead skin cells and avoid clogged up pores.

    Battles bacteria: sulfur has anti-bacterial properties, and, according to cheung, sulfur is a dermatologist-favorite due to the fact that it kills bacteria, fungi, and numerous parasites.

    Deals with delicate skin problem: cheung says because sulfur is anti-inflammatory and helps to soften and exfoliate thick, dead skin, it’s typically utilized to deal with acne, psoriasis, and seborrheic dermatitis or dandruff. Shah includes that it’s also known to treat eczema and rosacea. [8]

    How to utilize sulfur for skin?

    Sulfur is offered in a wide variety of skin care products, in addition to targeted acne treatments.

    People who wish to use sulfur on their skin can choose from:.

    • Cleansers
    • Creams
    • Exfoliants
    • Face cleans and lathers
    • Lotions
    • Face masks
    • Soaps
    • Spot treatments

    Sulfur products are available otc or with a prescription. They may include additional active components, such as resorcinol or sodium sulfacetamide.

    Individuals can use sulfur treatments alone or together with other acne treatments. Frequently, using a combination of treatments can assist acne recover much faster.

    For instance, people could use an otc sulfur face mask as soon as a week and a benzoyl peroxide wash each day. Alternatively, a skin doctor may recommend a topical retinoid for nighttime usage and a sulfur-based cleanser for morning usage.

    Carrying out a patch test

    Individuals need to always perform a patch test before using any new product on their skin. They can do this by using a percentage of the item to the within the arm and waiting 24 hr to monitor for negative effects.

    If no response takes place, it is likely safe to apply the item to the face or other parts of the body. If negative effects establish, it is a good idea to stop the use of the item. [9]

    Sulfur topical adverse effects

    Get emergency situation medical help if you have indications of an allergy: hives; hard breathing; swelling of your face, lips, tongue, or throat.

    Sulfur topical may cause serious adverse effects. Call your physician simultaneously if you have:.

    • Extreme burning, redness, or swelling where the medication was applied;
    • Serious dryness or peeling of dealt with skin; or
    • New or intensifying skin symptoms.

    Typical side effects of sulfur topical may include:.

    • Mild burning, tingling, stinging, itching, or soreness;
    • Peeling, dryness; or
    • Oily skin.

    This is not a complete list of side effects and others may take place. Call your doctor for medical guidance about negative effects. [10]


    The dosage of this medication will be various for different clients. Follow your physician’s orders or the instructions on the label. The following information consists of just the average doses of this medicine. If your dose is different, do not alter it unless your doctor informs you to do so.

    The amount of medicine that you take depends upon the strength of the medication. Likewise, the number of doses you take each day, the time permitted in between doses, and the length of time you take the medication depend on the medical problem for which you are using the medicine.

    For acne:

    For cream and bar soap dosage types:

    Adults and kids– utilize on the skin as needed.

    For lotion dose kind:

    Adults and children– use 2 or 3 times a day.

    For ointment dosage kind:

    Grownups and kids– utilize the 0.5% lotion on the skin as required.

    For seborrheic dermatitis:

    For ointment dose form:

    Grownups and children– use the 5 to 10% ointment one or two times a day.

    For scabies:

    For lotion dose form:

    Grownups and kids– use the 6% lotion each night for 3 nights.

    Missed out on dosage

    If you miss a dose of this medicine, take it as soon as possible. However, if it is nearly time for your next dosage, avoid the missed out on dosage and return to your routine dosing schedule. Do not double doses. [11]

    Special precautions and warnings

    Pregnancy and breast-feeding: sulfur is potentially safe when applied to the skin appropriately, short-term. Products containing sulfur in concentrations approximately 6% have actually been used safely nighttime for approximately 6 nights.

    Kids: sulfur is potentially safe when applied to the skin properly, short-term. Products including sulfur in concentrations approximately 6% have been used securely when applied nightly in children and teenagers for as much as 6 nights. Products including sulfur in concentrations as much as 2% have been utilized safely when obtained 3 hours daily for as much as 6 days in infants.

    Sulfa allergic reaction: it is commonly believed that people who dislike sulfa drugs might be allergic to sulfur including items. This is not true. People with an allergy to “sulfa” respond to the sulfonamide in some antibiotics and related drugs. They do not respond to elemental sulfur. [12]


    In this paper we have actually provided the variety and distribution of genes related to sulfur oxidation in 75 strains of thioalkalivibrio, a group of haloalkaliphilic and chemolithoautotrophic sob from soda lakes. We have actually shown that flavocytochrome c, the truncated sox system (soxaxyzb) and sulfite: quinone oxidoreductase (soeabc) exist in all stress. The path from essential sulfur to sulfite is presently not solved for all thioalkalivibrio, as only 6 genomes encode the dissimilatory sulfite reductase system. The hdr-like operon is a great candidate for sulfur oxidation, although the release of sulfite from this enzyme system has yet to be demonstrated. It is found in all dsr-negative strains and the genomes of 4 stress contain both, although the physiological effects of this are unknown.

    Hierarchical clustering showed that the sulfur gene repertoire of specific stress associates well with genomic groups previously defined by anib analysis. Phylogenetic analysis of soxb, fccb, and soea amino acid series declares the complex evolutionary history of thioalkalivibrio that was reported in previous analyses of 16s rrna and cbbl sequences. Genomic contexts of genes present in numerous copies show that there is generally one genotype with sequences from all stress and one or more genotypes additional copies that were most likely obtained through hgt.

    There are a variety of significant unsolved questions concerning the sulfur metabolic process of thioalkalivibrio, most especially the oxidation of essential sulfur as pointed out above. The in vivo function of the fad-dependent oxidoreductases that form a sis group to type ii sqr sequences provides another opportunity for further research study. [13]


    4. inorganic_chemistry)/ descriptive_chemistry/ elements_organized_by_group/ group_16% 3a_the_oxygen_family/ z016_chemistry_of_sulfur _( z16)

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