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Gotu Kola

    Centella asiatica, frequently referred to as gotu kola, kodavan, indian pennywort and asiatic pennywort, is an herbaceous, perennial plant in the flowering plant family apiaceae. It is native to wetlands in the caucasus, tropical & & subtropical vintage to new zealand and the west pacific. It is utilized as a culinary vegetable and as a medical herb. (1 )

    Overview

    Gotu kola (centella asiatica) is an herb in the parsley family. It has a long history of use in the traditional chinese and ayurvedic medication systems.

    Gotu kola contains certain chemicals that appear to reduce swelling and blood pressure. It also seems to increase collagen production, which might be valuable for injury recovery.

    Individuals utilize gotu kola for burns and bad flow that can lead to varicose veins. It is likewise used for scars, stretch marks, and many other conditions, however there is no good clinical evidence to support the majority of these usages. (2 ).

    History

    Gotu kola (centella asiatica) has been used to deal with numerous conditions for thousands of years in india, china, and indonesia. It was used to heal injuries, improve mental clarity, and treat skin conditions such as leprosy and psoriasis.

    Some individuals use it to treat respiratory infections, such as colds, and in the past it was used for that in china. It has been called “the water fountain of life” since legend has it that an ancient chinese herbalist lived for more than 200 years as a result of taking gotu kola.

    Historically, gotu kola has actually likewise been utilized to deal with syphilis, liver disease, stomach ulcers, psychological fatigue, epilepsy, diarrhea, fever, and asthma. Today, in the u.s. And europe gotu kola is most often used to treat varicose veins and persistent venous insufficiency, a condition where blood swimming pools in the legs. It is likewise used in ointments to treat psoriasis and help recover minor injuries.

    Gotu kola is not the like kola nut (soda pop nitida). Unlike kola nut, gotu kola does not have caffeine, and is not a stimulant. (3 ).

    Description

    Gotu kola (centella asiatica) is a member of the apiaceae carrot family. It is likewise called pennywort, marsh cent, water pennywort, and sheep rot. The name sheep rot comes from the erroneous belief in europe that gotu kola triggered foot rot in sheep. Gotu kola is typically incorrect for the kola nut plant (soda pop nitida). Nevertheless, the two are unrelated and gotu kola, unlike the kola nut, consists of no caffeine. Gotu kola is kept in mind in india as an extremely effective spiritual herb, and ayurvedic medication refers to it as brahmi due to the fact that it helps acquire understanding of the soul.

    Gotu kola, a perennial, grows in india, sri lanka, madagascar, south africa, china, indonesia, australia, and north america. It can grow like a weed, but its description depends on its location. For instance, in shallow water, the leaves float; however in dry areas, the plant establishes lots of roots and thin, tiny leaves. The fan-shaped leaves may be smooth or lobed. Red flowers become fruit with a size of about 0.2 in (5 mm).

    Gotu kola’s main active parts are triterpenoids, although the gotu kola discovered in india, sri lanka, and madagascar doesn’t have the same residential or commercial properties. Gotu kola’s triterpenes can have a concentration from 1.1-8%, with the majority of concentrations in the middle variety.

    Gotu kola from madagascar is utilized for the majority of standardized extracts, and its four main triterpene residential or commercial properties are:.

    • Asiatic acid (29-30%)
    • Madecassic acid (29-30%)
    • Asiaticoside (40%)
    • Madecassoside (1-2%)

    Gotu kola likewise consists of the following.

    • Volatile oil of a terpene acetate (36% of all the unpredictable oil)
    • Camphor
    • Cineole
    • Glycerides of some fats
    • Plant sterols (campesterol, stigmasterol, sitosterol)
    • Polyacetylene substances
    • Flavonoids (kampferol, quercetin)
    • Myo-inositol (glycoside from the flavonoids)
    • Sugars
    • Vellarin
    • Amino acids
    • Resins (4 )

    Scientific research studies

    The majority of the medical research studies on asian ca have been understood with alcoholic or aqueous extracts. The teca extracts (titrated extracts of asian ca and ttfca (triterpenic overall portion of asian ca) are mixes of asiatic acid (30%), madecasic acids (30%) and asiaticoside (40%). The ttf extract (triterpenic total fraction) consists of asian ca and madecasic acids (60%) in a relation not plainly specified yet, in combination with asiatichoside (40%). Both in vivo medical research studies and human monolayer cell culture experiments have concluded that asiatic acid affects collagen synthesis. The selective action of the regional application of triterpenoid portion of cae for injury healing and stressed the function of asiaticoside in the increased levels of antioxidants (enzymatic and nonenzymatic), which were also indicated for the sped up injury recovery. It is now known that angiogenesis plays a crucial function in injury healing considering that the freshly formed blood vessels assist the hypoxic injuries to achieve normoxic conditions. Asiaticoside prompted angiogenesis in both in vivo and in vitro models. In cases of vascular injury, thrombosis, acute myocardial infarction, and other peripheral vascular diseases, a higher variety of circulating endothelial cells was spotted. For example, in one study, clients with post phlebetic syndrome (pps) showed a greater number of flowing endothelial cells compared to the typical subjects. During a three-week treatment with ca triterpenic fraction (catf), pps patients who received 90 mg catf daily in three divided does showed a statistical significant decline in circulating endothelial cells, thus indicating the efficiency of ca in safeguarding the stability of vascular intima. The lower variety of flowing endothelial cells was credited to the protective impact of catf on vascular intima stability. The extract of ca was evaluated on 94 clients struggling with venous deficiency of the lower limbs. The clients were divided into three groups, each treated with teca (120 mg/day, 60 mg/day or placebo) for two months. An analytical significant difference in favour of teca groups was observed in the parameters looked for lower limbs and edema; likewise the general evaluation was revealed favorable for the teca cured groups compared to the placebo. Catf showed to be effective on microcirculation and capillary permeability. Fifty-two patients with venous high blood pressure (pressure greater than 42 mmhg) were divided into three groups, each treated with 60 mg/day, 30 mg/day, or placebo. The extra 10 control topics were treated with 60 mg/day. After 4 weeks of treatment considerable enhancements were observed in a concentration-dependent manner in the parameters evaluated, such as purification rate, ankle edema, and ankle circumference. No substantial modifications were observed in placebo and control subjects treated with catf. In another double-blind scientific trial including 87 patients with persistent venous hypertensive microangiopathy, two dosage types of catf (30 mg/day and 60 mg/day) were made an application for 60 days and no unwanted results were observed. The results also confirmed the effectiveness of catf in a dose-dependent manner. The effects of the catf on enzymes involved in mucopolysaccharide metabolism supported the hypothesis that the extract acts on fundamental metabolic process in the connective tissues of the vascular wall. The levels of basal serum uronic acid and enzymes involved in mucopolysaccharide metabolism (beta-glucuronidase, beta-n-acetylglucosaminidase, and arylsulfatase) were elevated in patients with varicose veins, suggesting an increased muco-polysaccharide turnover. After treatment (60 mg/day for three months) the above enzyme levels fell gradually.

    A double-blind, placebo-controlled research study was performed to examine the effects of an oral standardized ca product in 2 doses (30 mg bid and 60 mg bid) in 87 clients with chronic venous hypertensive microangiopathy. Microcirculatory specifications were revealed to be improved as compared to placebo in dosage dependent manner, with the higher dose enhancing symptoms more substantially. Another study reported the helpful effects of an oral standardized ca product (60 mg 3 times a day over a 2month period) in vascular permeability and microcirculation as examined by laser doppler flowmetry. The outcomes showed a combined enhancement of the microcirculation and capillary permeability in all clients (10 regular topics, 22 patients with moderate, shallow venous hypertension, and 12 clients with postphlebitic limbs and severe venous hypertension). Another research study in patients with severe venous high blood pressure due to deep venous illness reported that a standardized ca extract was acutely reliable in reducing capillary filtration and edema in people with venous hypertensive microangiopath. Ca preparations were found practical in decreasing the stretch marks (striae gravidarum) that numerous women establish during pregnancy. A placebo-controlled study of 100 pregnant females compared application of a cream including a cae, vitamin e (alpha tocopherol), and collagen-elastin hydrolysates to placebo. Application of the compounded cream was associated with fewer ladies developing stretch marks than in placebo. Application of topical ca preparations were revealed to be helpful in decreasing the scarring seen during wound recovery, seeming related to the stimulation of maturation of the scar by the production of type i collagen and the resulting decline in the inflammatory reaction and myofibroblast production. In a randomized, double-blind, vehicle-controlled, half-side comparison research study, undertaken to identify if it could likewise improve mild-to-moderate atopic dermatitis in adults, eighty-eight individuals were randomly applied the treatment lotion and the placebo control to either the left or best side of the body for 4 weeks (2 applications daily) after which erythema, edema, exuding, and excoriation were evaluated. No significant improvements were spotted in the treatment group as compared to the control group; however, more analysis of patients residing in chillier environments showed a substantial enhancement in the dealt with areas. Because the lotion consisted of the combination of herbs, it was suggested that further studies using each individual herb and research studies utilizing a parallel group style were required to be carried out.

    In one current randomized, placebo-controlled, double-blind research study, 28 individuals (< <61 years of age) received either ca extracts (250, 500, or 750 mg everyday) or placebo in order to determine the result of ca on cognitive function and state of mind. In the study, after 2 months, cognitive function (as assessed by event-related prospective and the digital evaluation battery test) and mood (utilizing bond-lader visual analogue) was determined. The greatest improvements in state of mind and cognitive function were found in those getting the 750 mg dose of ca extract. A double-blind, placebo-controlled research study examined the anxiolytic activity of ca in human topics. The authors concluded that the findings recommended ca’s anxiolytic activity in human beings. Extremely recently, a research study was performed in sixty elderly subjects in age group 65 and above, using diagnostic tools like mini mental state assessment scoring (mmse scoring), where activities of day-to-day living and yesavage geriatric depression scale were examined. The mean mmse scoring revealed considerable enhancement after administration of ca for 6 months in elderly with mild cognitive impairment (mci) at dose of 500 mg twice a day (1000 mg everyday). A beneficial improvement is observed in depression and other age associated conditions like hypertension, peripheral neuritis, insomnia, loss of appetite, irregularity indicative of numerous useful medical impacts of ca particularly in the age-related cognitive decline in elderly. (5 ).

    Advantages of gotu kola

    It might help boost cognitive function

    A small 2016 research study compared the effects of gotu kola extract and folic acid in boosting cognitive function after a stroke. This small study evaluated the effect on 3 groups of participants– one taking 1,000 milligrams (mg) of gotu kola per day, one taking 750 mg of gotu kola per day, and one taking 3 mg of folic acid daily.

    Although gotu kola and folic acid were equally advantageous in improving total cognition, gotu kola was more reliable in improving memory domain.

    A separate research study took a look at the cognitive enhancing impacts of gotu kola water extract on mice. Although both young and old mice showed improvements in learning and memory utilizing the morris water maze, the effect was greater in the older mice.

    How to use: take 750 to 1,000 mg of gotu kola daily for up to 2 week at a time.

    It may assist treat alzheimer’s illness

    Gotu kola has the ability to enhance memory and nerve function, which provides it prospective in dealing with alzheimer’s illness. In fact, one 2012 research study on mice discovered that gotu kola extract had a positive impact on behavioral irregularities in mice with alzheimer’s illness.

    The extract was also shown, in laboratory and animal studies, to have a modest result on securing brain cells from toxicity. This might also safeguard the cells from forming the plaque related to alzheimer’s.

    Still, additional research study is needed to identify exactly how gotu kola could be used to treat alzheimer’s. If you’re interested in including this to your treatment plan, talk with your doctor prior to use.

    How to use: take 30 to 60 drops of liquid gotu kola extract 3 times each day. Dosages may vary between producers, so constantly carefully follow the directions on the bottle.

    It might help in reducing anxiety and stress

    Researchers in an animal study from 2016 found that gotu kola had an anti-anxiety impact on male mice that were sleep deprived for 72 hours. Sleep deprivation can cause anxiety, oxidative damage, and neuro swelling.

    Mice that were given gotu kola for 5 consecutive days prior to going through sleep deprivation experienced substantially less anxiety-like behavior. They also experienced enhanced locomotor activity and less oxidative damage.

    A 2013 review of anti-anxiety organic medicines also concluded that gotu kola has an acute anti-anxiety result. Nevertheless, more research study is needed to verify these findings.

    How to utilize: take 500 mg of gotu kola extract twice a day for up to 14 days at a time. You can use up to 2,000 mg daily in cases of extreme stress and anxiety.

    It may act as an antidepressant

    Gotu kola’s positive result on brain function might also make it a reliable antidepressant.

    An evaluation from 2016 supports these findings, in part due to a study on 33 individuals with generalized anxiety condition. The individuals were asked to take gotu kola in place of their antidepressant medication for 60 days. They self-reported reduced stress, stress and anxiety, and depression.

    Another research study talked about in the evaluation evaluated the effect of gotu kola on rats caused with chronic depression. The herbal treatment had a positive impact on specific elements of behavioral anxiety, consisting of body weight, body temperature level, and heart rate.

    How to utilize: take 500 mg of gotu kola twice a day for up to 2 week at a time. You can use up to 2,000 mg per day during times of magnified anxiety.

    It might improve flow and decrease swelling

    Research study from 2001 found that gotu kola can decrease problems with fluid retention, ankle swelling, and flow connected to taking flights that last longer than three hours.

    Individuals who experienced mild-to-moderate superficial venous disease with varicose veins were asked to take gotu kola for two days prior to their flight, the day of their flight, and the day after their flight.

    Researchers discovered that participants who took the supplement experienced substantially less fluid retention and ankle swelling than those who didn’t.

    Older research has likewise shown that gotu kola can be beneficial in treating varicose veins. This may be since gotu kola has a favorable metabolic impact on the connective tissue of the vascular wall.

    How to utilize: take 60 to 100 mg of gotu kola draw out 3 times each day for a week, prior to and after any flights. You can also massage the affected location with a topical cream consisting of 1 percent gotu kola extract.

    How to do a skin patch test: it is essential to do a patch test before utilizing any topical medication. To do this, rub a dime-sized amount on to the within your forearm. If you do not experience any irritation or swelling within 24 hr, it should be safe to use elsewhere.

    It might help relieve sleeping disorders

    Provided its perceived ability to treat stress and anxiety, tension, and depression, gotu kola may likewise be utilized to treat the insomnia that in some cases accompanies these conditions. Some consider this herbal remedy to be a safe alternative to prescription medications utilized to deal with sleeping disorders and other sleep disorders.

    Although older research study does suggest that gotu kola can help deal with sleep conditions, additional studies are needed to verify these findings.

    How to use: take 300 to 680 mg of gotu kola extract 3 times each day for as much as 2 week at a time.

    It might help reduce appearance of stretch marks

    According to a 2013 evaluation, gotu kola can reduce the look of stretch marks. It’s believed that the terpenoids discovered in gotu kola boost collagen production in the body. This may assist prevent brand-new stretch marks from forming, in addition to assistance recover any existing marks.

    How to use: use a topical cream consisting of 1 percent gotu kola extract to the affected area numerous times each day.

    How to do a skin patch test: it’s important to do a patch test prior to utilizing any topical medication. To do this, rub a dime-sized amount on to the inside of your forearm. If you do not experience any irritation or inflammation within 24 hr, it must be safe to use in other places.

    It might promote injury healing and reduce scarring

    Researchers in a 2015 study on rats discovered that wound dressing consisting of gotu kola had healing results on multiple types of wounds. This consists of clean cuts by sharp objects, irregular tears triggered by blunt-force injury, and infected tissue.

    Although promising, additional research is required to confirm these findings.

    How to utilize: use an ointment containing 1 percent gotu kola extract to the afflicted area a number of times each day. If your injury is deep or otherwise serious, see your physician prior to use.

    How to do a skin patch test: it’s important to do a patch test prior to using any topical medication. To do this, rub a dime-sized amount on to the inside of your lower arm. If you do not experience any irritation or inflammation within 24 hours, it ought to be safe to use elsewhere.

    It may assist alleviate joint pain

    The anti-inflammatory residential or commercial properties of gotu kola might work in treating arthritis.

    In fact, one 2014 study on collagen-induced arthritis in rats discovered that oral administration of gotu kola minimized joint swelling, cartilage disintegration, and bone erosion. Its antioxidant result likewise had a positive result on the body immune system.

    How to utilize: take 300 to 680 mg of gotu kola extract 3 times daily for as much as 14 days at a time.

    It might have a detox result

    More recent research study is having a look at gotu kola’s impact on liver and kidney toxicity.

    According to one 2017 animal study, gotu kola can be used to reduce the poisonous side effects of the antibiotic isoniazid. Isoniazid is used to treat and avoid tuberculosis.

    Rats were offered 100 mg of gotu kola for 1 month prior to they were provided the antibiotic. These rats experienced less toxicity overall. Rats that did experience toxicity in the liver and kidneys resumed to near-normal levels after being given gotu kola.

    More research study is required to expand upon these findings.

    How to use: take 30 to 60 drops of liquid gotu kola draw out 3 times daily for up to 14 days at a time. Does might vary between producers, so constantly carefully follow the instructions on the bottle. (6 ).

    Nutritional realities

    In southeast asia, gotu kola is used as much for food when it comes to medical purposes. A member of the parsley household, gotu kola is an excellent source of essential vitamins and minerals needed to preserve optimal health.

    According to an evaluation in the international food research study journal, 100 grams of fresh gotu kola delivers the following nutrients and satisfies the following recommended dietary intake (rdi) needs:.

    • Calcium: 171 milligrams (17% of the rdi)
    • Iron: 5.6 milligrams (31% of the rdi)
    • Potassium: 391 milligrams (11% of the rdi)
    • Vitamin a: 442 micrograms (49% of the rdi)
    • Vitamin c: 48.5 milligrams (81% of the rdi)
    • Vitamin b2: 0.19 milligrams (9% of the rdi)

    gotu kola is also a great source of dietary fiber, providing 8 percent of the rdi for females and 5 percent of the rdi for men. (7 ).

    Benefits of gotu kola in your skin care products

    Gotu kola is abundant with antioxidants. It enhances the skin’s capability to ward off ecological stress factors that can wreak havoc on your skin, and dispels impurities that can bring about indications of premature aging like dark areas, wrinkles, and dull skin.

    It has cleaning properties. It rids your face of yuck and muck like dirt, bacteria, and pore-clogging oil (advantage it remains in our mild so clean! Cleanser).

    It can brighten, tighten, and smooth skin. Because of this it can drastically decrease the look of scarring, fine lines, and wrinkles. It’s also incredible for your eye location, which is why we have actually included it in our eyes baby eye cream, as it can lessen the look of dark circles and puffiness. In general, it will renew and revitalize your skin assisting you feel fresh faced and amazing!

    It’s a super soother. Full of soothing homes, gotu kola decreases short-term inflammation and alleviates pain connected with skin level of sensitivity. This makes it a fantastic active ingredient to look for if you have sensitive skin.

    It’s a majorly efficient hydration station. Gotu kola aids the skin in maintaining wetness and can help achieve that vibrant, fresh glow that only originates from correct amounts of water. This is what makes it a key ingredient in our crème de la cream moisturizer. Hydrated skin is the ultimate method to keep common signs of aging at bay. (8 ).

    Adverse effects of gotu kola

    Some reported side effects of gotu kola include:

    • Sleepiness
    • Intestinal discomfort
    • Skin issues
    • Dizziness
    • Nausea
    • Headaches

    Although there is minimal relevant data, it is possible that gotu kola can engage with prescription or non-prescription medications.

    It is important to speak with a medical professional prior to utilizing gotu kola. Make certain that the physician understands about all ongoing medications and treatments. (9 )

    Gotu kola tea recipe and benefit

    Gotu kola (indian pennywort or mandukparni, centella asiatica, hydrcotyle asiatica) is a medical herb, which is utilized in ayurveda from centuries to treat brain function associated problems such as poor memory, low brainpowers, anxiety, speech issues and sleeplessness. Gotu kola tea, which is prepared from the plant of centella asiatica is simple to make and offers lots of health benefits. This tea is specifically useful in causing sound sleep.

    For preparing this tea, one teaspoon of finely shredded dried/fresh gotu kola leaves are taken in a cup of warm water. The cup is covered with lid and the leaves are soaked for 10-15 minutes. After fifteen minutes tea is ready to consume. For more powerful taste, you can steep leaves for more time. You can prepare and consume this tea 3-4 times a day.

    Gotu kola tea uses various health benefits. It is brain tonic, which reduces stress, anxiety, tumors, and remedies insomnia/sleeplessness and anxiety. It also improves mental abilities, memory, intellect and eliminates psychological tiredness. Gotu kola tea removes contaminants from the liver and blood, enhances energy levels and enhances the kidneys. According to ayurveda, it stabilizes intensified vata and pitta in the body. (10 ).

    Dosing

    The recommended everyday dose of titrated extracts of c. Asiatica standardized for asiaticoside, asiatic acid, and madecassic acid is 60 to 120 mg. (11 ).

    Interaction

    Taking gotu kola with any medications that make you drowsy can worsen this effect. Ask your healthcare provider before taking gotu kola with medication for anxiety, depression, or seizures.

    Gotu kola can hurt your liver. This impact is increased when you also use other medicines hazardous to the liver. Do not take gotu kola without medical suggestions if you are utilizing any of the following medications:.

    • Acetaminophen (tylenol);
    • Leflunomide, teriflunomide;
    • Methotrexate;
    • An antibiotic, antifungal medicine, sulfa drug, or tuberculosis medication;
    • Contraceptive pill or hormone replacement therapy;
    • Heart or high blood pressure medication;
    • Cholesterol-lowering medications– crestor, lipitor, pravachol, simcor, vytorin, zocor, and others;
    • Gout or arthritis medications (consisting of gold injections);
    • Hiv/aids medications;
    • Medicines to treat mental disorder;
    • An nsaid (non-steroidal anti-inflammatory drug)- ibuprofen (advil, motrin), naproxen (aleve), celecoxib (celebrex), diclofenac, indomethacin, meloxicam, others;
    • Seizure medication– carbamazepine, phenytoin, and others; or
    • Steroids (prednisone and others).

    This list is not total. Other drugs may connect with gotu kola, consisting of prescription and over the counter medications, vitamins, and organic items. Not all possible interactions are listed in this item guide. (12 ).

    Warnings

    This medication includes gotu kola. Do not use brahmabuti, centella asiatica, hydrocotyle, indian pennywort, indian water navelwort, madescassol, marsh penny, talepetrako, thick-leaved pennywort, or white rot if you dislike gotu kola or any components contained in this drug.

    Keep out of reach of children. In case of overdose, get medical assistance or contact a poison nerve center instantly. (13 ).

    Conclusions

    Asiatica is an herb used in standard chinese medication. Its primary reliable elements are asiaticoside, asiatic acid, madecassoside, and madecassic acid. As discussed earlier, c. Asiatica and its triterpenoids have a vast array of medical values. In vivo and in vitro studies showed that c. Asiatica and its triterpenoids had restorative and eliminating impacts on multi-system diseases. The c. Asiatica extract efficiently eliminates sleep deprivation, advertisement, type 2 diabetes mellitus (t2dm), hyperlipidemia, gestational diabetes, baldness, atopic dermatitis, wound, drug-induced liver toxicity, liver injury, gastric mucosal injury, stomach ulcers, breast cancer, leukemia, oral submucous fibrosis, migraine, etc. Asiatic acid efficiently eliminates cognitive disability, alzheimer’s disease, parkinson’s disease, obesity, renovascular high blood pressure, transverse aortic constriction, myocardial ischemia/reperfusion (mi/r) injury, atherosclerosis, liver fibrosis, intense pancreatitis, colon carcinogenesis, hepatocellular carcinoma, lung fibrosis, lung cancer, pelvic inflammatory, ovarian cancer, endometriosis, sepsis, periodontitis, and so forth. The preclinical studies on asiaticoside discovered that it has therapeutic capacity for the following illness: hemiparkinsonism, alzheimer’s disease, cerebral anemia, skin injury, lung high blood pressure, atherogenesis, ali, osteolytic bone illness, etc. Pharmacological studies discovered that madecassoside had prospective healing impact versus osteoporosis, acne, vitiligo, ra, and so forth. Madecassic acid had a positive healing effect on ischemic retinopathies. The preclinical research study on centella asiatica generally focused on the extract of c. Asiatica and asiatic acid. For diseases, neurological and skin diseases are primarily examined. However, the influence on other diseases likewise needs more in-depth exploration.

    The event of inflammatory response, oxidative tension, apoptosis, and mitochondrial dysfunction is carefully related to different illness. C. Asiatica and its triterpenoids can be used in numerous medical circumstances because they have anti-inflammatory and anti-apoptotic effects, ease oxidant stress, and enhance mitochondrial function. Thus further, c. Asiatica might also be applied to diseases not pointed out in this research study through the very same pathological mechanism, and this hypothesis needs extensive investigation for confirmation. (14 ).

    Recommendations

    1. Https://en.wikipedia.org/wiki/centella_asiatica
    2. Https://www.webmd.com/vitamins/ai/ingredientmono-753/gotu-kola
    3. Https://www.mountsinai.org/health-library/herb/gotu-kola
    4. Https://www.encyclopedia.com/medicine/encyclopedias-almanacs-transcripts-and-maps/gotu-kola
    5. Https://www.ncbi.nlm.nih.gov/pmc/articles/pmc3116297/
    6. Https://www.healthline.com/health/gotu-kola-benefits#_noheaderprefixedcontent
    7. Https://www.verywellhealth.com/the-benefits-of-gotu-kola-89566
    8. Https://fleurandbee.com/blogs/news/gotu-kola-for-skin
    9. Https://www.medicalnewstoday.com/articles/gotu-kola-benefits#side-effects
    10. Https://www.bimbima.com/recipes/gotu-kola-tea-recipe-and-benefits/2292/
    11. Https://www.drugs.com/npp/gotu-kola.html
    12. Https://www.emedicinehealth.com/drug-gotu_kola/article_em.htm#drugs
    13. Https://www.rxlist.com/consumer_gotu_kola/drugs-condition.htm
    14. Https://www.frontiersin.org/articles/10.3389/fphar.2020.568032/full#h4

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